Andrew Santino was born and raised in the Chicago area, where he developed a love for comedy at a young age. He began performing stand-up while still in high school, and after graduation, he pursued a career in comedy full-time.
In addition to his stand-up work, Santino has also made appearances on TV shows such as The League, Mixology, and The Disaster Artist, and he has lent his voice to animated shows such as American Dad and Family Guy. He is also the host of two popular podcasts: "Whiskey Ginger", a weekly podcast where he typically has a fellow comic or actor on as a guest, as well as "Bad Friends", with co-host Bobby Lee.
Santino is known for his energetic and animated stage presence, and his comedy often centers on his observations of daily life and pop culture. He continues to perform stand-up regularly, and he has also released several comedy albums and specials.